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Energy Sciences

Lawrence Berkeley National Laboratory

Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides

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https://doi.org/10.1039/c7sc00691h
Abstract

A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl, thiazolyl, and oxazolyl halides were efficiently difluoromethylated, thus providing medicinal chemists an alternative choice for the preparation of drug candidates with the difluoromethylated heteroarene unit.

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