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Muc5b is required for airway defence
- Roy, Michelle G;
- Livraghi-Butrico, Alessandra;
- Fletcher, Ashley A;
- McElwee, Melissa M;
- Evans, Scott E;
- Boerner, Ryan M;
- Alexander, Samantha N;
- Bellinghausen, Lindsey K;
- Song, Alfred S;
- Petrova, Youlia M;
- Tuvim, Michael J;
- Adachi, Roberto;
- Romo, Irlanda;
- Bordt, Andrea S;
- Bowden, M Gabriela;
- Sisson, Joseph H;
- Woodruff, Prescott G;
- Thornton, David J;
- Rousseau, Karine;
- De la Garza, Maria M;
- Moghaddam, Seyed J;
- Karmouty-Quintana, Harry;
- Blackburn, Michael R;
- Drouin, Scott M;
- Davis, C William;
- Terrell, Kristy A;
- Grubb, Barbara R;
- O’Neal, Wanda K;
- Flores, Sonia C;
- Cota-Gomez, Adela;
- Lozupone, Catherine A;
- Donnelly, Jody M;
- Watson, Alan M;
- Hennessy, Corinne E;
- Keith, Rebecca C;
- Yang, Ivana V;
- Barthel, Lea;
- Henson, Peter M;
- Janssen, William J;
- Schwartz, David A;
- Boucher, Richard C;
- Dickey, Burton F;
- Evans, Christopher M
Published Web Location
https://doi.org/10.1038/nature12807Abstract
The airway mucin Muc5b (but not Muc5ac) is required for mucociliary clearance, defence against bacterial infection in the airways and middle ear, and maintenance of immune homeostasis in the lungs; Muc5b deficiency causes accumulation of apoptotic macrophages, impairment of phagocytosis and reduced production of interleukin-23, leading to infection and inflammation.
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