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Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia
- Joshi, Ila;
- Yoshida, Toshimi;
- Jena, Nilamani;
- Qi, Xiaoqing;
- Zhang, Jiangwen;
- Van Etten, Richard A;
- Georgopoulos, Katia
Published Web Location
https://doi.org/10.1038/ni.2821Abstract
Ikaros deletions are associated with certain human malignancies. Georgopoulos and colleagues show that loss of Ikaros arrests B lymphoid progenitors at an adherent and proliferative pre-B cell stage from which leukemia can arise.
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