Medical Student Research Forum Posters

Tuberous Sclerosis (TS) is a genetic disorder that affects multiple organ systems and is associated with growth of non-malignant hamartomas throughout the body. The disease is highly associated with seizures, cognitive impairments, and behavioral or social deficits such as ASD or ADHD.

There have been various studies examining the association between TS and intellectual and behavioral outcomes for young patients using event related potentials (ERPs) obtained on EEG. This includes the Mismatch Negativity (MMN) ERP. The measurement of these potentials is a reliable, non-invasive method to compare brain activity patterns across subjects. Following from previous study data, we want to explore specific, altered patterns of electrical activity in TS patients with ASD that are distinct from those found in TS patients without ASD.