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Glomerular Filtration Rate (GFR) Measurement by Iohexol Plasma Clearance in an Ethnically Diverse Living Donor Population
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Abstract
An accurate determination of Glomerular Filtration Rate (GFR) is essential in the evaluation of living kidney donors. The gold standard measurement of GFR is urinary clearance of inulin, which is a cumbersome and difficult testing process. Iohexol is a non-ionic contrast agent with low extrarenal excretion, tubular secretion or reabsorption, and protein binding affinity, and is therefore a good agent for measurement of GFR (mGFR).
Iohexol has also been found to be virtually non-toxic, with low cost and can yield mGFR with one timed blood draw.
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