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Synthesis and Explosion Hazards of 4‑Azido‑l‑phenylalanine
Published Web Location
https://doi.org/10.1021/acs.joc.8b00270Abstract
A reliable, scalable, cost-effective, and chromatography-free synthesis of 4-azido-l-phenylalanine beginning from l-phenylalanine is described. Investigations into the safety of the synthesis reveal that the Ullman-like Cu(I)-catalyzed azidation step does not represent a significant risk. The isolated 4-azido-l-phenylalanine product, however, exhibits previously undocumented explosive characteristics.
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