Skip to main content
eScholarship
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Synthesis and Explosion Hazards of 4-Azido-l-phenylalanine.

  • Author(s): Richardson, Mark B;
  • Brown, Derek B;
  • Vasquez, Carlos A;
  • Ziller, Joseph W;
  • Johnston, Kevin M;
  • Weiss, Gregory A
  • et al.
Abstract

A reliable, scalable, cost-effective, and chromatography-free synthesis of 4-azido-l-phenylalanine beginning from l-phenylalanine is described. Investigations into the safety of the synthesis reveal that the Ullman-like Cu(I)-catalyzed azidation step does not represent a significant risk. The isolated 4-azido-l-phenylalanine product, however, exhibits previously undocumented explosive characteristics.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View