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Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development
- Au-Yeung, Byron B;
- Melichar, Heather J;
- Ross, Jenny O;
- Cheng, Debra A;
- Zikherman, Julie;
- Shokat, Kevan M;
- Robey, Ellen A;
- Weiss, Arthur
Published Web Location
https://doi.org/10.1038/ni.2918Abstract
TCR ligation activates the kinase Zap70. Weiss and colleagues, utilizing 'analog-sensitive' Zap70 cells, show that thymocyte positive and negative selection exhibit differential temporal requirements for Zap70 signaling.
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