This comment letter responds to the National Institutes of Health’s (NIH) proposed Biosafety Policy for Research Involving Biohazards. UC supports efforts to streamline biosafety oversight but recommends clarifying the policy’s scope, preserving institutional authority to conduct risk-based assessments, and reducing unnecessary administrative and reporting requirements, particularly because ambiguous or overly broad requirements could increase compliance burdens, create inconsistent institutional practices, and unnecessarily delay research.