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Big bottlenecks in cardiovascular tissue engineering.
- Huang, Ngan F;
- Serpooshan, Vahid;
- Morris, Viola B;
- Sayed, Nazish;
- Pardon, Gaspard;
- Abilez, Oscar J;
- Nakayama, Karina H;
- Pruitt, Beth L;
- Wu, Sean M;
- Yoon, Young-Sup;
- Zhang, Jianyi;
- Wu, Joseph C
Published Web Location
https://doi.org/10.1038/s42003-018-0202-8Abstract
Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.
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