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Open Access Publications from the University of California

Big bottlenecks in cardiovascular tissue engineering.

  • Author(s): Huang, Ngan F
  • Serpooshan, Vahid
  • Morris, Viola B
  • Sayed, Nazish
  • Pardon, Gaspard
  • Abilez, Oscar J
  • Nakayama, Karina H
  • Pruitt, Beth L
  • Wu, Sean M
  • Yoon, Young-Sup
  • Zhang, Jianyi
  • Wu, Joseph C
  • et al.

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

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