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Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far.

  • Author(s): Xu, Yijun
  • Ding, Vivianne W
  • Zhang, Hong
  • Zhang, Xun
  • Jablons, David
  • He, Biao
  • et al.

Compared to adenocarcinoma, fewer effective treatment options are available for advanced or metastatic squamous cell carcinoma (SCC) of the lung. Afatinib is an orally administered, irreversible EGFR antagonist. As a second-generation tyrosine kinase inhibitor, it has been applied in the treatment of patients with EGFR-mutant non-small-cell lung cancer. Recently, several clinical trials have shown that afatinib leads to a significant improvement in progression-free survival and overall survival of patients with SCC. Moving forward, afatinib should be one of the options among tyrosine kinase inhibitors, monoclonal antibodies, and cytotoxicity chemotherapy drugs for SCC.

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