Skip to main content
eScholarship
Open Access Publications from the University of California

Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration

  • Author(s): Lopez, CA
  • Miller, BM
  • Rivera-Chávez, F
  • Velazquez, EM
  • Byndloss, MX
  • Chávez-Arroyo, A
  • Lokken, KL
  • Tsolis, RM
  • Winter, SE
  • Bäumler, AJ
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127919/
No data is associated with this publication.
Abstract

Copyright © 2016 by the American Association for the Advancement of Science; all rights reserved. Citrobacter rodentium uses a type III secretion system (T3SS) to induce colonic crypt hyperplasia in mice, thereby gaining an edge during its competition with the gutmicrobiota through an unknown mechanism. Here, we sho wthat by triggering colonic crypt hyperplasia, the C. rodentium T3SS induced an excessive expansion of undifferentiated Ki67-positive epithelial cells, which increased oxygenation of themucosal surface and drove an aerobic C. rodentium expansion in the colon. Treatment ofmice with the g-secretase inhibitor dibenzazepine to diminish Notch-driven colonic crypt hyperplasia curtailed the fitness advantage conferred by aerobic respiration during C. rodentium infection. We conclude that C. rodentium uses its T3SS to induce histopathological lesions that generate an intestinal microenvironment in which growth of the pathogen is fueled by aerobic respiration.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item