Skip to main content
Open Access Publications from the University of California


UC San Francisco Previously Published Works bannerUCSF

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

  • Author(s): Ng, Maggie CY;
  • Shriner, Daniel;
  • Chen, Brian H;
  • Li, Jiang;
  • Chen, Wei-Min;
  • Guo, Xiuqing;
  • Liu, Jiankang;
  • Bielinski, Suzette J;
  • Yanek, Lisa R;
  • Nalls, Michael A;
  • Comeau, Mary E;
  • Rasmussen-Torvik, Laura J;
  • Jensen, Richard A;
  • Evans, Daniel S;
  • Sun, Yan V;
  • An, Ping;
  • Patel, Sanjay R;
  • Lu, Yingchang;
  • Long, Jirong;
  • Armstrong, Loren L;
  • Wagenknecht, Lynne;
  • Yang, Lingyao;
  • Snively, Beverly M;
  • Palmer, Nicholette D;
  • Mudgal, Poorva;
  • Langefeld, Carl D;
  • Keene, Keith L;
  • Freedman, Barry I;
  • Mychaleckyj, Josyf C;
  • Nayak, Uma;
  • Raffel, Leslie J;
  • Goodarzi, Mark O;
  • Chen, Y-D Ida;
  • Taylor, Herman A;
  • Correa, Adolfo;
  • Sims, Mario;
  • Couper, David;
  • Pankow, James S;
  • Boerwinkle, Eric;
  • Adeyemo, Adebowale;
  • Doumatey, Ayo;
  • Chen, Guanjie;
  • Mathias, Rasika A;
  • Vaidya, Dhananjay;
  • Singleton, Andrew B;
  • Zonderman, Alan B;
  • Igo, Robert P;
  • Sedor, John R;
  • FIND Consortium;
  • Kabagambe, Edmond K;
  • Siscovick, David S;
  • McKnight, Barbara;
  • Rice, Kenneth;
  • Liu, Yongmei;
  • Hsueh, Wen-Chi;
  • Zhao, Wei;
  • Bielak, Lawrence F;
  • Kraja, Aldi;
  • Province, Michael A;
  • Bottinger, Erwin P;
  • Gottesman, Omri;
  • Cai, Qiuyin;
  • Zheng, Wei;
  • Blot, William J;
  • Lowe, William L;
  • Pacheco, Jennifer A;
  • Crawford, Dana C;
  • eMERGE Consortium;
  • DIAGRAM Consortium;
  • Grundberg, Elin;
  • MuTHER Consortium;
  • Rich, Stephen S;
  • Hayes, M Geoffrey;
  • Shu, Xiao-Ou;
  • Loos, Ruth JF;
  • Borecki, Ingrid B;
  • Peyser, Patricia A;
  • Cummings, Steven R;
  • Psaty, Bruce M;
  • Fornage, Myriam;
  • Iyengar, Sudha K;
  • Evans, Michele K;
  • Becker, Diane M;
  • Kao, WH Linda;
  • Wilson, James G;
  • Rotter, Jerome I;
  • Sale, Michèle M;
  • Liu, Simin;
  • Rotimi, Charles N;
  • Bowden, Donald W;
  • MEta-analysis of type 2 DIabetes in African Americans Consortium
  • et al.

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View