Skip to main content
eScholarship
Open Access Publications from the University of California

Potentiation of anandamide hypotension by the transport inhibitor, AM404

  • Author(s): Calignano, A
  • La Rana, G
  • Beltramo, M
  • Makriyannis, A
  • Piomelli, D
  • et al.
Abstract

The putative endogenous cannabinoid, anandamide (0.2-2 mg/kg i.v.), decreased systemic blood pressure dose-dependently in anesthesized guinea pigs. These effects were prevented by the CB1 cannabinoid receptor antagonist SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1 -(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide · HCl] at the dose of 0.2 mg/kg i.v. The vasodepressor responses to anandamide were significantly potentiated and prolonged by a novel inhibitor of carrier-mediated anandamide transport, N-(4-hydroxyphenyl) arachidonylethanolamide (AM404) (10 mg/kg, i.v.). These results suggest that anandamide transport participates in terminating the vascular actions of anandamide.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View