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Open Access Publications from the University of California

UC Response to NIH Pause on New Submissions to the NIH Human Embryonic Stem Cell Registry and Request for Information on Reducing Reliance on Human Embryonic Stem Cells in NIH-Supported Research (NOT-OD-26-031)

Abstract

This comment letter responds to the National Institutes of Health (NIH)'s Pause on New Submissions to the NIH Human Embryonic Stem Cell Registry and Request for Information on Reducing Reliance on Human Embryonic Stem Cells in NIH-Supported Research. The University of California (UC) opposes reducing reliance on human embryonic stem cells (hESCs) at this time, arguing that hESCs remain essential research tools and critical benchmarks for evaluating alternative stem cell technologies. UC recommends that any future transition be evidence-based, adequately funded, and phased in gradually, while also urging NIH to continue accepting new hESC lines into the Registry to support scientific progress, reproducibility, and clinical translation.