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Fatal Metformin Overdose Presenting with Progressive Hyperglycemia

  • Author(s): Suchard, Jeffrey R
  • Grotsky, Thomas A
  • et al.
Abstract

A 29-year-old man with no history of diabetes ingested over 60 grams of metformin in a suicide attempt. He presented to the emergency department with acute renal insufficiency, severe lactic acidosis, and rapidly-progressive hyperglycemia. The patient’s peak serum glucose level of 707 mg/dL is the highest yet reported in a case of metformin toxicity. Treatment included sodium bicarbonate infusion and hemodialysis, but the patient suffered several cardiac arrests with pulseless electrical activity and ultimately expired 25 hours after the ingestion.

[WestJEM. 2008;9:160-164.]

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