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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
- Mahajan, Anubha;
- Go, Min Jin;
- Zhang, Weihua;
- Below, Jennifer E;
- Gaulton, Kyle J;
- Ferreira, Teresa;
- Horikoshi, Momoko;
- Johnson, Andrew D;
- Ng, Maggie CY;
- Prokopenko, Inga;
- Saleheen, Danish;
- Wang, Xu;
- Zeggini, Eleftheria;
- Abecasis, Goncalo R;
- Adair, Linda S;
- Almgren, Peter;
- Atalay, Mustafa;
- Aung, Tin;
- Baldassarre, Damiano;
- Balkau, Beverley;
- Bao, Yuqian;
- Barnett, Anthony H;
- Barroso, Ines;
- Basit, Abdul;
- Been, Latonya F;
- Beilby, John;
- Bell, Graeme I;
- Benediktsson, Rafn;
- Bergman, Richard N;
- Boehm, Bernhard O;
- Boerwinkle, Eric;
- Bonnycastle, Lori L;
- Burtt, Noël;
- Cai, Qiuyin;
- Campbell, Harry;
- Carey, Jason;
- Cauchi, Stephane;
- Caulfield, Mark;
- Chan, Juliana CN;
- Chang, Li-Ching;
- Chang, Tien-Jyun;
- Chang, Yi-Cheng;
- Charpentier, Guillaume;
- Chen, Chien-Hsiun;
- Chen, Han;
- Chen, Yuan-Tsong;
- Chia, Kee-Seng;
- Chidambaram, Manickam;
- Chines, Peter S;
- Cho, Nam H;
- Cho, Young Min;
- Chuang, Lee-Ming;
- Collins, Francis S;
- Cornelis, Marilyn C;
- Couper, David J;
- Crenshaw, Andrew T;
- van Dam, Rob M;
- Danesh, John;
- Das, Debashish;
- de Faire, Ulf;
- Dedoussis, George;
- Deloukas, Panos;
- Dimas, Antigone S;
- Dina, Christian;
- Doney, Alex SF;
- Donnelly, Peter J;
- Dorkhan, Mozhgan;
- van Duijn, Cornelia;
- Dupuis, Josée;
- Edkins, Sarah;
- Elliott, Paul;
- Emilsson, Valur;
- Erbel, Raimund;
- Eriksson, Johan G;
- Escobedo, Jorge;
- Esko, Tonu;
- Eury, Elodie;
- Florez, Jose C;
- Fontanillas, Pierre;
- Forouhi, Nita G;
- Forsen, Tom;
- Fox, Caroline;
- Fraser, Ross M;
- Frayling, Timothy M;
- Froguel, Philippe;
- Frossard, Philippe;
- Gao, Yutang;
- Gertow, Karl;
- Gieger, Christian;
- Gigante, Bruna;
- Grallert, Harald;
- Grant, George B;
- Groop, Leif C;
- Groves, Christopher J;
- Grundberg, Elin;
- Guiducci, Candace;
- Hamsten, Anders;
- Han, Bok-Ghee;
- Hara, Kazuo;
- Hassanali, Neelam;
- Hattersley, Andrew T;
- Hayward, Caroline;
- Hedman, Asa K;
- Herder, Christian;
- Hofman, Albert;
- Holmen, Oddgeir L;
- Hovingh, Kees;
- Hreidarsson, Astradur B;
- Hu, Cheng;
- Hu, Frank B;
- Hui, Jennie;
- Humphries, Steve E;
- Hunt, Sarah E;
- Hunter, David J;
- Hveem, Kristian;
- Hydrie, Zafar I;
- Ikegami, Hiroshi;
- Illig, Thomas;
- Ingelsson, Erik;
- Islam, Muhammed;
- Isomaa, Bo;
- Jackson, Anne U;
- Jafar, Tazeen;
- James, Alan;
- Jia, Weiping;
- Jöckel, Karl-Heinz;
- Jonsson, Anna;
- Jowett, Jeremy BM;
- Kadowaki, Takashi;
- Kang, Hyun Min;
- Kanoni, Stavroula;
- Kao, Wen Hong L;
- Kathiresan, Sekar;
- Kato, Norihiro;
- Katulanda, Prasad;
- Keinanen-Kiukaanniemi, Sirkka M;
- Kelly, Ann M;
- Khan, Hassan;
- Khaw, Kay-Tee;
- Khor, Chiea-Chuen;
- Kim, Hyung-Lae;
- Kim, Sangsoo;
- Kim, Young Jin;
- Kinnunen, Leena;
- Klopp, Norman;
- Kong, Augustine;
- Korpi-Hyövälti, Eeva;
- Kowlessur, Sudhir;
- Kraft, Peter;
- Kravic, Jasmina;
- Kristensen, Malene M;
- Krithika, S;
- Kumar, Ashish;
- Kumate, Jesus;
- Kuusisto, Johanna;
- Kwak, Soo Heon;
- Laakso, Markku;
- Lagou, Vasiliki;
- Lakka, Timo A;
- Langenberg, Claudia;
- Langford, Cordelia;
- Lawrence, Robert;
- Leander, Karin;
- Lee, Jen-Mai;
- Lee, Nanette R;
- Li, Man;
- Li, Xinzhong;
- Li, Yun;
- Liang, Junbin;
- Liju, Samuel;
- Lim, Wei-Yen;
- Lind, Lars;
- Lindgren, Cecilia M;
- Lindholm, Eero;
- Liu, Ching-Ti;
- Liu, Jian Jun;
- Lobbens, Stéphane;
- Long, Jirong;
- Loos, Ruth JF;
- Lu, Wei;
- Luan, Jian'an;
- Lyssenko, Valeriya;
- Ma, Ronald CW;
- Maeda, Shiro;
- Mägi, Reedik;
- Männistö, Satu;
- Matthews, David R;
- Meigs, James B;
- Melander, Olle;
- Metspalu, Andres;
- Meyer, Julia;
- Mirza, Ghazala;
- Mihailov, Evelin;
- Moebus, Susanne;
- Mohan, Viswanathan;
- Mohlke, Karen L;
- Morris, Andrew D;
- Mühleisen, Thomas W;
- Müller-Nurasyid, Martina;
- Musk, Bill;
- Nakamura, Jiro;
- Nakashima, Eitaro;
- Navarro, Pau;
- Ng, Peng-Keat;
- Nica, Alexandra C;
- Nilsson, Peter M;
- Njølstad, Inger;
- Nöthen, Markus M;
- Ohnaka, Keizo;
- Ong, Twee Hee;
- Owen, Katharine R;
- Palmer, Colin NA;
- Pankow, James S;
- Park, Kyong Soo;
- Parkin, Melissa;
- Pechlivanis, Sonali;
- Pedersen, Nancy L;
- Peltonen, Leena;
- Perry, John RB;
- Peters, Annette;
- Pinidiyapathirage, Janani M;
- Platou, Carl GP;
- Potter, Simon;
- Price, Jackie F;
- Qi, Lu;
- Radha, Venkatesan;
- Rallidis, Loukianos;
- Rasheed, Asif;
- Rathmann, Wolfgang;
- Rauramaa, Rainer;
- Raychaudhuri, Soumya;
- Rayner, N William;
- Rees, Simon D;
- Rehnberg, Emil;
- Ripatti, Samuli;
- Robertson, Neil;
- Roden, Michael;
- Rossin, Elizabeth J;
- Rudan, Igor;
- Rybin, Denis;
- Saaristo, Timo E;
- Salomaa, Veikko;
- Saltevo, Juha;
- Samuel, Maria;
- Sanghera, Dharambir K;
- Saramies, Jouko;
- Scott, James;
- Scott, Laura J;
- Scott, Robert A;
- Segrè, Ayellet V;
- Sehmi, Joban;
- Sennblad, Bengt;
- Shah, Nabi;
- Shah, Sonia;
- Shera, A Samad;
- Shu, Xiao Ou;
- Shuldiner, Alan R;
- Sigurðsson, Gunnar;
- Sijbrands, Eric;
- Silveira, Angela;
- Sim, Xueling;
- Sivapalaratnam, Suthesh;
- Small, Kerrin S;
- So, Wing Yee;
- Stančáková, Alena;
- Stefansson, Kari;
- Steinbach, Gerald;
- Steinthorsdottir, Valgerdur;
- Stirrups, Kathleen;
- Strawbridge, Rona J;
- Stringham, Heather M;
- Sun, Qi;
- Suo, Chen;
- Syvänen, Ann-Christine;
- Takayanagi, Ryoichi;
- Takeuchi, Fumihiko;
- Tay, Wan Ting;
- Teslovich, Tanya M;
- Thorand, Barbara;
- Thorleifsson, Gudmar;
- Thorsteinsdottir, Unnur;
- Tikkanen, Emmi;
- Trakalo, Joseph;
- Tremoli, Elena;
- Trip, Mieke D;
- Tsai, Fuu Jen;
- Tuomi, Tiinamaija;
- Tuomilehto, Jaakko;
- Uitterlinden, Andre G;
- Valladares-Salgado, Adan;
- Vedantam, Sailaja;
- Veglia, Fabrizio;
- Voight, Benjamin F;
- Wang, Congrong;
- Wareham, Nicholas J;
- Wennauer, Roman;
- Wickremasinghe, Ananda R;
- Wilsgaard, Tom;
- Wilson, James F;
- Wiltshire, Steven;
- Winckler, Wendy;
- Wong, Tien Yin;
- Wood, Andrew R;
- Wu, Jer-Yuarn;
- Wu, Ying;
- Yamamoto, Ken;
- Yamauchi, Toshimasa;
- Yang, Mingyu;
- Yengo, Loic;
- Yokota, Mitsuhiro;
- Young, Robin;
- Zabaneh, Delilah;
- Zhang, Fan;
- Zhang, Rong;
- Zheng, Wei;
- Zimmet, Paul Z;
- Altshuler, David;
- Bowden, Donald W;
- Cho, Yoon Shin;
- Cox, Nancy J;
- Cruz, Miguel;
- Hanis, Craig L;
- Kooner, Jaspal;
- Lee, Jong-Young;
- Seielstad, Mark;
- Teo, Yik Ying;
- Boehnke, Michael;
- Parra, Esteban J;
- Chambers, John C;
- Tai, E Shyong;
- McCarthy, Mark I;
- Morris, Andrew P
Published Web Location
https://doi.org/10.1038/ng.2897Abstract
Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.
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