Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management
- Author(s): Lebin, Jacob A.
- LeSaint, Kathy T.
- et al.
Published Web Locationhttps://doi.org/10.5811/westjem.2020.5.47810
As of April 21, 2020, more than 2.5 million cases of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, have been reported in 210 countries and territories, with the death toll at 171,810. Both chloroquine and hydroxychloroquine have gained considerable media attention as possible therapies, resulting in a significant surge in demand. In overdose, both medications can cause severe, potentially life-threatening effects. Here, we present a brief overview of the pharmacology of chloroquine and hydroxychloroquine, manifestations of toxicity, and treatment considerations.