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IMG-ABC: An Atlas of Biosynthetic Gene Clusters to Fuel the Discovery of Novel Secondary Metabolites

  • Author(s): Chen, I-Min
  • Chu, Ken
  • Ratner, Anna
  • Palaniappan, Krishna
  • Huang, Jinghua
  • Reddy, T.B.K.
  • Cimermancic, Peter
  • Fischbach, Michael
  • Ivanova, Natalia
  • Markowitz, Victor
  • Kyrpides, Nikos
  • Pati, Amrita
  • et al.
Abstract

In the discovery of secondary metabolites (SMs), large-scale analysis of sequence data is a promising exploration path that remains largely underutilized due to the lack ofrelevant computational resources. We present IMG-ABC (https://img.jgi.doe.gov/abc/) -- An Atlas of Biosynthetic gene Clusters within the Integrated Microbial Genomes(IMG) system1. IMG-ABC is a rich repository of both validated and predicted biosynthetic clusters (BCs) in cultured isolates, single-cells and metagenomes linked withthe SM chemicals they produce and enhanced with focused analysis tools within IMG. The underlying scalable framework enables traversal of phylogenetic dark matter and chemical structure space -- serving as a doorway to a new era in the discovery of novel molecules.

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